NMR screening techniques in drug discovery and drug design

New approaches for NMR screening in drug discovery.

NMR spectroscopy has become a powerful and versatile tool in pharmaceutical research, particularly for studies of protein-ligand interactions. During the past few years, new NMR screening techniques have been developed. Some of them aim to increase sensitivity, which translates directly into higher throughput and/or decrease of protein consumption. Other approaches introduce completely new scre...

Structure-based drug design: NMR-based approach for ligand-protein interactions.

The realization of the powerfulness in analyzing ligand-protein interactions at the atomic resolution has made NMR techniques increasingly attractive in drug discovery and development. With some significant new method developments during the past few years, NMR-based approaches will undoubtedly be helpful in high throughput screening and in providing structural and interaction information benef...

***Removed from the Issue*** Application of Cell-Based Assay Systems for the Early Screening of Human Drug Hepatotoxicity in the Discovery Phase of Drug Development

Using NMR for ligand discovery and optimization.

Several recent technology-driven advances in the area of NMR have rekindled an interest in the application of the technology to problems in drug discovery and development. A unique aspect of NMR is that it has applicability in broadly different areas of the drug discovery and optimization processes. NMR techniques for screening aimed at the discovery of novel ligands or low molecular weight str...

Withdrawing of Article ''Application of Cell-Based Assay Systems for the Early Screening of Human Drug Hepatotoxicity in the Discovery Phase of Drug Development''